GERMINOMA MEDIASTINUM PDF

The mediastinum is the most common extragonadal location. In adults, approximately % of mediastinal tumors are germ cell tumors;. 20% of mediastinal tumors and cysts; Typically divided into seminomas versus nonseminomatous germ cell tumors (teratomas [mature or. Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. They most commonly occur in the gonad but occasionally.

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However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with chemotherapy using bleomycinetoposide and cisplatin for either three or four day treatment cycles depending on the location of any metastatic disease. In addition to physical examination and routine laboratory studies, initial evaluation should include CT of the chest and abdomen, and determination of serum levels of HCG and alpha-fetoprotein. Germ cell tumors[TI] mediastinum.

Wikipedia articles that are too technical from Medisstinum All articles that are too technical Articles needing expert attention from April All articles needing expert attention Infobox medical condition All articles with vague or ambiguous time Vague or ambiguous time from April Non-small-cell lung carcinoma Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.

Germ cell tumors of the mediastinum.

May have aggressive behavior if not limited to mediastinum at diagnosis Cancer ; By using this site, you agree to the Terms of Use and Privacy Germinnoma. Mesothelioma Malignant solitary fibrous tumor. Among the malignant germ cell tumors, males are affected far more commonly than females, but the male to female ratio is approximately equal among mature cystic teratomas.

The intense staining pattern of OCT4 and the high sensitivity of FISH make them superior to other auxiliary diagnostic utilities for detecting seminoma. Am J Surg Pathol. New author database being installed, click here for details. Thymic seminoma with marked cystic changes, superior mediastinum. These results and those of other analyses suggest that the two malignancies derive from a common founding clone of cells i.

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Unencapsulated, homogenous fleshy mass with indistinct boundaries and invasion of adjacent structures, hemorrhage or necrosis. Unlike benign germ cell tumors of the mediastinum, malignant mediastinal tumors are usually symptomatic at the time of diagnosis.

Germinoma-seminoma is the most germiinoma nonteratomatous malignant germ cell tumor.

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Germ cell tumor – mixed. Views Read Edit View history. Fetus in fetu Dermoid cyst Struma ovarii Strumal carcinoid Trophoblastic neoplasm: Sarcoma Grminoma Immature teratoma Melanoma. Some investigators suggest that this distribution mediaetinum as a consequence of abnormal migration of germ cells during embryogenesis. Gestational trophoblastic disease Hydatidiform mole Choriocarcinoma Placental site trophoblastic tumor Polyembryoma Gonadoblastoma.

Others hypothesize a widespread distribution of germ cells to multiple sites during normal embryogenesis, with these cells conveying genetic information or providing regulatory functions at somatic sites.

Mediastijum by regions G. In several of these cases, the genetic aberrations in the malignant megakaryoblasts were similar to those in the malignant mediastianl germ cells. Please help improve it to make it understandable to non-expertswithout removing the technical details.

Home About Us Advertise Medjastinum. Immunohistochemical staining for OCT4 has recently been validated as a powerful tool for detecting gonadal seminoma. Page views in to date: Pathology by systems F. Sign up for our Email Newsletters.

Germ cell tumors of the mediastinum.

However, discrepancies between the genetic alterations and immunoprofiles of mediastinal and testicular seminomas have been reported, raising the question of whether techniques that are useful in the diagnosis of gonadal seminoma are applicable to its mediastinal counterpart.

Click here for patient related inquiries. Retrieved from ” https: Metastatic germ cell tumor: Syndromes associated with mediastinal germ cell tumors include Hematologic Neoplasia and Klinefelter’s syndrome.

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Accessed December 31st, This article may be too technical for most readers to understand.

Info – Admin Resources in pathology Technical section. Usually males ages 20 – 49 years, similar to gonadal tumors Cancer ; Mediastinal germ mesiastinum tumors are tumors that derive from germ cell rest remnants in the mediastinum.

Semin Respir Crit Care Med. Also in this section mediastinal synovial sarcoma mediastinal low-grade extraskeletal osteosarcoma mediastinal pericytic tumors mediastinal leiomyosarcoma mediastinal leiomyoma mediastinal mesenchymal tumors mediastinal tumors mediastinal smooth muscle tumors mediastinal lymphomas mediastinal extramedullary hematopoietic tumor.

This website is intended for pathologists and laboratory personnel, who understand that medical mediastinumm is imperfect and must be interpreted using reasonable medical judgment.

In these cases, the mediastinal germ cell tumor develops before or concomitantly with but not after acute megakaryoblastic leukemia. Case report mexiastinum review of the literature”. April Learn how and when to remove this template message.

mediastinal germinoma – – Human pathology

The treatment for mediastinal nonseminomatous germ cell tumors should follow guidelines for poor-prognosis testicular cancer. Histologic grading of pure teratomas has prognostic significance in those neoplasms that are diagnosed in adolescents and young adults; immature teratomas in the latter patients pursue an aggressive clinical course.

Pancoast tumor Solitary pulmonary medaistinum Central lung Peripheral lung Bronchial leiomyoma. Initial treatment with four courses of mediastunum, etoposide, and cisplatin, followed by surgical resection of any residual disease, is considered standard therapy.

The nonteratomatous germinal neoplasms have the same morphologic features, approximate distribution, and prognosis as the gonadal counterparts. Seminomas grow relatively slowly and can become very large before causing symptoms.

Nasal cavity Esthesioneuroblastoma Nasopharynx Nasopharyngeal carcinoma Nasopharyngeal angiofibroma Larynx Laryngeal cancer Laryngeal papillomatosis.