Pathogens and Their Weaponization. Geoffrey Zubay. Columbia University Press . Agents of Bioterrorism. Google Preview. Pub Date: February Download Citation on ResearchGate | On Jan 1, , Geoffrey Zubay and others published Agents of Bioterrorism: Pathogens and their Weaponization }. [Book Review: Agents of Bioterrorism: Pathogens and Their Weaponization.] Article in The Quarterly Review of Biology 81(3) · September with 5.

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Pahhogens comment will be reviewed and published at the journal’s discretion. Legal Challenges Presented by Bioterrorism. Rickettsial aerosolization would provide an additional compounding factor, because it requires both a high degree of scientific expertise and a well-equipped, rather sophisticated facility.

Recrudescent typhus may have been the mechanism for the dissemination of R. Because of their unique biological characteristics environmental stability, small size, aerosol transmission, persistence in infected hosts, low infectious dose, high morbidity, and substantial mortalityR.

Pathogens and Their Weaponization Geoffrey L. bioyerrorism

He has published more than research papers and several books, including Biochemistry ; Genetics ; and Origins of Life on the Earth and in the Cosmos. Columbia University Press Amazon. Receive exclusive offers and updates from Oxford Academic. During later stages of infection, patients appear to be delirious and exhibit neurologic symptoms, including stupor.

Pathogens and Their Weaponization. The authors examine thirteen disease-causing agents, including those responsible for anthrax, the plague, smallpox, influenza, and SARS. Email alerts New issue alert. The Search for Vaccines. Woodward, for his insightful contributions to our knowledge of epidemic and murine typhus.

Even today, many cases of rickettsial diseases will never be diagnosed. Citing articles via Web of Science Account Options Sign in. You have entered an invalid code. Preventive measures are complicated because of the lack of effective and safe rickettsial vaccines [ 11 ].


Comparison of selected rickettsial pathogens with examples of bacteria used in biological warfare. Related articles in Web of Science Google Scholar. The book also examines strategies for making vaccines and protecting the population in a bioterror attack.

Bioterrorism: pathogens as weapons.

A similar situation could also exist for other rickettsial pathogens that are endemic in an affected area. The ease with which these epidemics can spread within crowded human weaponizahion has made their causative agents attractive to nations, for use as battlefield weapons, or to terrorists, for use as weapons of mass destruction or civil disruption [ 123—4 ].

In the United States, drastic increases in the number of cases of murine typhus in the anf, Rocky Mountain spotted fever RMSF in the late s, and human ehrlichioses in the s attest to the potential emergence of these infections in at-risk populations [ 16 ]. This new work offers a clear and thorough account of the threats posed by bioterrorism from the perspective of biologists.

Latest Most Read Most Cited Sequelae of congenital cytomegalovirus cCMV following maternal primary biotertorism are limited to those acquired in the first trimester of pregnancy.

Another drawback to developing rickettsial pathogens as biological weapons is their lack of direct transmission from host to host and the availability of very effective therapeutic countermeasures against these obligate intracellular bacteria. Pathogenz, mass production of rickettsial pathogens and the procedures required for their aerosolization are highly hazardous.

Bioterrorism: pathogens as weapons.

It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Initiating the proper treatment and curtailing outbreaks is the most crucial step, because prompt initiation of antibiotic treatment would prevent people from becoming ill and from dying. The severity of rickettsial disease has been associated with pathogen virulence and host-related factors e.

Because the disease is still endemic in highlands and cold areas of Africa, Asia, and Central and South America, as well as in parts of Eastern Europe, determining the source of infection would be difficult. Please check for further notifications by email. The conditions that allow for the coexistence of body lice and a susceptible population could be the starting point for a bioterrorism-initiated infection, because the release of the rickettsiae would set off a subsequent chain reaction.


Prophylactic measures are badly needed, because population growth and increased land use bring arthropods and their associated pathogens into human habitations.

Other editions – View all Agents of Bioterrorism: Close mobile search navigation Article navigation. Each chapter considers a particular pathogen The present article is dedicated to the memory of Dr.

Contents How to Cope I.

In addition, acquisition of rickettsial pathogens from reservoir hosts would be a daunting task requiring time-consuming protocols to patjogens pure and virulent isolates.

Rickettsiae are maintained in nature in their arthropod vectors, via transovarial and transstadial transmission, and human infection occurs accidentally through either a bite from the infected arthropod or contact with Rickettsia -laden feces.

Rickettsioses are a good example of diseases whose importance is not adequately appreciated, except by patients.

Pathogenic Rickettsiae as Bioterrorism Agents | Clinical Infectious Diseases | Oxford Academic

Biological Attributes Of Rickettsial Pathogens. However, from time to time, these infections have reemerged in epidemic form in human populations e. How to Cope I. Intentional release of R.

Knowledge of the transmission cycle would play an important role in identifying the initial source of an epidemic. Oxford University Press is a department of the University of Oxford. These biological attributes would make adn pathogenic rickettsiae desirable bioterrorism agents.